Spejlneuroner

- et state-of-the-art review

Forfattere

DOI:

https://doi.org/10.7146/tdm.v14i2.158260

Nøgleord:

spejlneuroner, evidens, funktion, musikterapi, hjerneforskning

Resumé

Spejlneuroner er en type af neuroner som blev opdaget i makak-abehjernen for mere end 20 år siden. Disse neuroner vagte opsigt, da de både var aktive når aben udførte og observerede handlinger. Siden opdagelsen er spejlneuroner blevet knyttet til forskellige funktioner som empati, imitation, handlingsforståelse samt autismespektrumsforstyrrelse. I dette state-of-the-art review diskuteres disse antagelser med afsæt i nyligt udgivne reviews. Ni artikler blev inkluderet i den endelige analyse. Ifølge disse artikler er der direkte evidens for tilstedeværelsen af neuroner med spejlfunktion i menneskehjernen. Funktionen heraf kendes dog ikke. Evidensgrundlaget for, at spejlneuroner er involverede i empati, imitation og autismespektrumsforstyrrelse, er enten mangelfuldt eller negativt. Der er en vis grad af evidens for, at områder i menneskehjernen, som antages at indeholde spejlneuroner, er involverede i handlingsforståelse. For at styrke teorierne om spejlneuroners funktion bør fremtidig forskning anvende enkelt-cellemålinger og opstille kontrollerede eksperimenter.

Referencer

Baird, A. D., Scheffer, I. E., & Wilson, S. J. (2011). Mirror neuron system involvement in empathy: a critical look at the evidence. Social Neuroscience, 6(4), 327-35.

Bauer, J. (2006). Hvorfor jeg føler det du føler – intuitiv kommunikation og hemmeligheden ved spejlneuroner. Valby, DK: Borgens Forlag.

Bjarkam, C. R. (2013). Nervesystemets opbygning, celler og funktion. In H. B. Vuust (Ed.), Hjernen – fra celle til samfund (pp. 14-34). Aarhus: DK: Systime.

Boso, M., Politi, P., Barale, F., & Emanuele, E. (2006). Neurophysiology and neurobiology of the musical experience. Functional Neurology, 21(4), 187-191.

Breedlove, S. M., & Watson, N. V. (2013). Biological psychology. An introduction to behavioral, cognitive, and clinical neuroscience (7th ed.). Sunderland, Massachusetts: Sinauer Associates.

Catmur, C. (2015). Understanding intentions from actions: Direct perception, inference, and the roles of mirror and mentalizing systems. Consciousness and Cognition, 36, 426-433.

Chanda, M. L., & Levitin, D. J. (2013). The neurochemistry of music. Trends in Cognitive Sciences, 17(4), 179-191.

Christodoulou, J. A., & Gaab, N. (2009). Using and misusing neuroscience in education-related research. Cortex, 45(4), 555-557.

Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., & Iacoboni, M. (2006). Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience, 9(1), 28-30.

Di Pellegrino, G., Fadiga, L., Fogassi, L., Gallese, V., & Rizzolatti, G. (1992). Understanding motor events: a neurophysiological study. Experimental Brain Research, 91(1), 176-180.

Fadiga, L., Fogassi, L., Pavesi, G., & Rizzolatti, G. (1995). Motor Facilitation During Action Observation: A Magnetic Stimulation Study. Journal of Neurophysiology, 73(6), 2608-2611.

Fan, Y.-T. T., Decety, J., Yang, C.-Y. Y., Liu, J.-L. L., & Cheng, Y. (2010). Unbroken mirror neurons in autism spectrum disorders. J Child Psychol Psychiatry, 51(9), 981-8.

Gallese, V., Gernsbacher, M. a., Heyes, C., Hickok, G., & Iacoboni, M. (2011). Mirror Neuron Forum. Perspectives on Psychological Science, 6(4), 369-407.

Geretsegger, M., Elefant, C., Mössler, K., & Gold, C. (2014). Music therapy for people with autism spectrum disorder ( Review ). Cochrane Database of Systematic Reviews, (6), 66.

Grafton, S. T., Arbib, M. A., Fadiga, L., & Rizzolatti, G. (1996). Localization of grasp representations in humans by positron emission tomography. Experimental Brain Research, 112(1), 103-111.

Hamilton, A. F. D. C. (2013). Reflecting on the mirror neuron system in autism: A systematic review of current theories. Developmental Cognitive Neuroscience, 3(1), 91-105.

Hamilton, A. F. D. C., Brindley, R. M., & Frith, U. (2007). Imitation and action understanding in autistic spectrum disorders : How valid is the hypothesis of a deficit in the mirror neuron system? Neuropsychologia, 45(8), 1859-1868.

Hartwigsen, G., Kassuba, T., & Sieber, H. R. (2010). Combining transcranial magnetic stimulation with (f)MRI. In S. Ulmer & O. Jansen (Eds.), fMRI: Basics and clinical applications (pp. 155-168). Berlin, DE: Springer Publishing Company.

Herculano-Houzel, S., Collins, C. E., Wong, P., & Kaas, J. H. (2007). Cellular scaling rules for primate brains. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 104(9), 3562-3567.

Hillecke, T., Nickel, A., & Bolay, H. V. (2005). Scientific perspectives on music therapy. Annals of the New York Academy of Sciences, 1060, 271-282.

Iacoboni, M., Woods, R. P., Brass, M., Bekkering, H., John, C., Rizzolatti, G., … Brass, M. (1999). Cortical Mechanisms of Human Imitation. Science, 286(5449), 2526-2528.

Jarrett, C. (2015). Great Myths of the Brain. West Sussex: Wiley.

Jarrett, C. B. (2012). Mirror neurons: the most hyped concept in Neuroscience? Retrieved October 25, 2016, from http://www.psychologytoday.com/blog/brain-myths/ 201212/mirror-neurons-the-most-hyped-concept-inneuroscience.%0A5.

Kilner, J. M., & Lemon, R. N. (2013). What we know currently about mirror neurons. Current Biology, 23(23), 1057-1062.

Koelsch, S. (2009). A neuroscientific perspective on music therapy. Annals of the New York Academy of Sciences, 1169, 374-384.

Kolb, B., & Whishaw, I. Q. (2009). Fundamentals of human neuropsychology (6th ed.). New York, NY: Worth Publishers.

Lamm, C., & Majdandzic, J. (2015). The role of shared neural activations, mirror neurons, and morality in empathy – A critical comment. Neuroscience Research, 90, 15-24.

Levitin, D. J. (2013). Neural correlates of musical behaviours. Music Therapy Perspectives, 31, 15-24.

Martineau, J., Andersson, F., Barthélémy, C., Cottier, J. P., & Destrieux, C. (2010). Atypical activation of the mirror neuron system during perception of hand motion in autism. Brain Research, 1320, 168-175.

Michael, J., Sandberg, K., Skewes, J., Wolf, T., Blicher, J., Overgaard, M., & Frith, C. D. (2014). Continuous theta-burst stimulation demonstrates a causal role of premotor homunculus in action understanding. Psychological Science, 25(4), 963-72.

Molenberghs, P., Cunnington, R., & Mattingley, J. B. (2012). Brain regions with mirror properties: A meta-analysis of 125 human fMRI studies. Neuroscience and Biobehavioral Reviews, 36(1), 341-349.

Mukamel, R., Ekstrom, A. D., Kaplan, J., Iacoboni, M., & Fried, I. (2010). Single-Neuron Responses in Humans during Execution and Observation of Actions. Current Biology, 20(8), 750-756.

O’Kelly, J. (2016). Music Therapy and Neuroscience: Opportunities and Challenges Lessons from Neuroscience. Voices: A World Forum for Music Therapy, 16(2), 1-25.

Oberman, L. M., Hubbard, E. M., McCleery, J. P., Altschuler, E. L., Ramachandran, V. S., & Pineda, J. A. (2005). EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Cognitive Brain Research, 24(2), 190-198.

Ramachandran, V. S. (2011). The Tell-Tale Brain: A Neuroscientist’s Quest for What Makes Us Human. Norton, New York: W.W. Norton & company.

Raymaekers, R., Wiersema, J. R., & Roeyers, H. (2009). EEG study of the mirror neuron system in children with high functioning autism. Brain Research, 1304, 113-121.

Rizzolatti, G., Cattaneo, L., Fabbri-Destro, M., & Rozzi, S. (2014). Cortical mechanisms underlying the organization of goal-directed actions and mirror neuron-based action understanding. Physiological Reviews, 94(2), 655-706.

Rizzolatti, G., Fadiga, L., Gallese, V., & Fogassi, L. (1996). Premotor cortex and the recognition of motor actions. Cognitive Brain Research, 3(2), 131-141.

Robson, C., & McCartan, K. (2016). Real World Research (4th ed.). West Sussex: Wiley.

Southgate, V., & Hamilton, A. F. D. C. (2008). Unbroken mirrors : challenging a theory of Autism. Trends in Cognitive Sciences, 12(6), 225-229.

Särkämö, T., Tervaniemi, M., Laitinen, S., Numminen, A., Kurki, M., Johnson, J. K., & Rantanen, P. (2014). Cognitive, emotional, and social benefits of regular musical activities in early dementia: Randomized controlled study. Gerontologist, 54(4), 634-650.

Williams, J. H. G., Waiter, G. D., Gilchrist, A., Perrett, D. I., Murray, A. D., & Whiten, A. (2006). Neural mechanisms of imitation and “mirror neuron” functioning in autistic spectrum disorder. Neuropsychologia, 44(4), 610-621.

Downloads

Publiceret

2017-11-15

Citation/Eksport

Anderson-Ingstrup, J. (2017). Spejlneuroner: - et state-of-the-art review. Tidsskriftet Dansk Musikterapi, 14(2), 3–16. https://doi.org/10.7146/tdm.v14i2.158260